Localization of neurons containing pro-opiomelanocortin-related peptides in the hypothalamus and midbrain of the lizard, Anolis carolinensis: evidence for region-specific processing of beta-endorphin.
نویسندگان
چکیده
Immunohistochemical analyses of the lizard-brain, following colchicine pretreatment, revealed two populations of POMC-producing cell bodies located in medial-basal hypothalamus and the mesencephalic tegmentum. Analyses of extracts of lizard brain regions by radioimmunoassay and gel filtration chromatography indicate that beta-endorphin-sized and alpha-MSH-sized peptides are the major POMC-related end products. Evidence is presented for region-specific processing of beta-endorphin in the lizard brain.
منابع مشابه
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The aims of the present experiments were: 1) to test whether substances which modulate beta-endorphin-immunoreactive (BE-ir) release from the pituitary gland might act similarly in hypothalamic tissue; and 2) to further characterize the BE-ir forms which are released from hypothalamus. To address these questions, hypothalamic tissue was incubated in vim for 10 min periods in either normal media...
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ورودعنوان ژورنال:
- Brain research
دوره 324 2 شماره
صفحات -
تاریخ انتشار 1984